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This program is designed to detect genetically abnormal subjects in a case-control sample based on genotypes at multiple marker loci. For a full explanation of the method, see the paper: A quick and simple method for detecting subjects with abnormal genetic background in case-control samples. Curtis D, North BV, Gurling HMD, Blaveri E, Sham PC. 2002 Ann Hum Genet.
The program reads in genotypes of at a number of markers and for each marker constructs a measure of how unusual that genotype is, given the frequencies of its alleles in the whole sample. This measure is then summed over all markers for that subject and a permutation test is then used to identify any subjects which have an unusually high total measure for having unusual genotypes across all markers.
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